Aerobic Training in Patients With Multiple

One possible explanation for this result is the size of the standard deviations of the measurements, which might be related to the wide range of Expanded Disability Status Scale (EDSS) scores permitted for patient inclusion. We are aware that a smaller range of EDSS scores would have selected a more homogeneous sample of subjects and probably would have reduced the size of the standard deviations. However, we chose to include subjects with mild to moderate disability subjects in the study in order to assess the effect and the feasibility of aerobic training in people with moderate disability as well. We also are aware that, in order to improve our ability to intervene in terms of mode and intensity of exercise, a better classification of subjects with multiple sclerosis as well as other diseases is needed. Although the EDSS is the most widely used rating scale for people with multiple sclerosis, it shows some limitations1,2 because it appears to be poorly sensitive to clinical change and has limited ability to distinguish among individuals in terms of their disability. Thus, we need new measures to assess both impairment and disability in people with multiple sclerosis. Consequently, the Multiple Sclerosis Functional Composite (MSFC) has been proposed by Cutter et al,3 and it recently has been found to be more sensitive than the EDSS in detecting changes in function as a result of regular exercise.4 However, the MSFC requires further validation in rehabilitation trials.